She weighed over 650 pounds (Picture: TLC screengrab)

Lisa Fleming, a woman who appeared on the series My 600lb Life has died at the age of 50.

The tragic news of her death was announced by her daughter Danielle on Facebook.

On Thursday, her devastated daughter wrote: I am truly at a loss for words right now. God knows I wanted you to hold on until I got here but He knew what was best for me. I didnt need to see you like that!

Mommy, I love you from here to the stars and back! she added.

Danielle told TMZ that her mothers death was not weight related, and that in fact, she recently lost 200 pounds.

At the end she was sick and her body was tired and her body just gave out, she said.

Her daughter said she held her mothers hand for four hours before she died.

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Lisa had been featured on season six of the reality weight loss show in February, where she spoke of her struggles with weight. The 50 year old revealed that problems with her weight began as a child when she witnessed the murder of her brother.

Lisa had been on a quest to improve her health on the show as her life had spiralled out of control and she had found maggots in the folds of her skin. She had been bedridden for that time and found it difficult to care for herself.

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It had taken seven paramedics to remove her from her bed.

Lisa is the second person featured on the show to pass away in a month.

The first was L B Bonner, who was also heavily overweight and died by suicide earlier this month.

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