Kevin Systrom and Mike Krieger have announced they will step down from Instagram – six years after it was bought by Facebook.
In a statement, the duo said they would step down to "explore our curiosity again".
They said: "Mike and I are grateful for the last eight years at Instagram and six years with the Facebook team. We've grown from 13 people to over a thousand with offices around the world, all while building products used and loved by a community of over one billion. We're now ready for our next chapter.
"We're planning on taking some time off to explore our curiosity and creativity again. Building new things requires that we step back, understand what inspires us and match that with what the world needs; that's what we plan to do.
"We remain excited for the future of Instagram and Facebook in the coming years as we transition from leaders to two users in a billion. We look forward to watching what these innovative and extraordinary companies do next."
Facebook boss Mark Zuckerberg said: "Kevin and Mike are extraordinary product leaders and Instagram reflects their combined creative talents. I've learned a lot working with them for the past six years and have really enjoyed it.
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"I wish them all the best and I'm looking forward to seeing what they build next."