One Mega Millions ticket has matched all six numbers and will claim a $450m (£332m) grand prize.
The ticket was sold in Florida, lottery officials said, but no winner was immediately announced.
The winning numbers drawn on Friday night were 28-30-39-59-70-10.
It is the fourth largest jackpot prize in the game's history and the 10th largest in US lottery history, reports said.
Chances of winning the Mega Millions lottery stood at about one in 303 million.
The win came as lottery fever hit the US, with the other national lottery, Powerball, offering a jackpot of $570m (£420m).
The two lotteries had gone months without a jackpot winner. The Powerball is on Saturday night.
Together, the two jackpots constitute the third-largest ever jackpot combined total.
Lottery fever has quickly spread across the US, with eager punters queuing up outside convenience stores to buy the $2 (£1.50) tickets.
Shop assistant Kaushik Chitalia said: "There are some people coming in the store and they say like 'We are buying the big dream."
Lottery ticket customer Martin Turk of Richmond, Texas said: "I don't normally do it, but this is just, I felt it today something told me to go buy a ticket."
Another customer, Tom Newman, who said he would spend the money on his family and travelling around the world, admitted he wasn't feeling optimistic: "Like absolutely zero chance, but a tiny bit more than zero, so that's why I bothered wasting the money."
But despite the lotteries promising winnings adding up to $1.2bn (£884m), most winners wouldn't actually chose to take home the maximum amount of cash.
Instead of opting for the publicised jackpot figure, which is paid out over an annuity paid over 29 years, most lottery winners choose to take a lump sum payment.
The cash payout for the Powerball draw would be around $358.5m (£264m), while the Mega Millions lump sum is around $281m (£207m).
Whichever option the lucky winners choose, the US taxman will also do well from the deal, who will take around 37% of the winning lump sum.
The chances of winning the Powerball jackpots are one in 292 million.
Last year, Americans spent $80.5bn (£59.3m) on lottery tickets and scratch cards, according to the North American Association of State and Provincial Lotteries.
More from Lottery
The largest Powerball jackpot to date was a $1.6bn (£1.2bn) payout, split three ways in January 2016.
The largest Mega Millions jackpot was $656m (£484m), won in 2012, and also shared by three lucky winners.
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Sky News
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