As the scale and threat of the COVID-19 pandemic became clear, researchers who trace the spread of diseases were pretty unanimous: to buy us time to develop a therapy or vaccine, countries needed to implement heavy-handed restrictions to limit the opportunities for the virus to spread. Experts painted frightening pictures of huge peaks of infections that would overwhelm local hospital systems if lockdowns weren't put in place, leading to many unnecessary deaths. For countries like Italy and Spain, which were already in the throes of an uncontrolled spread, reality bore these predictions out. Peaks rose sharply in advance of restrictions but fell nearly as sharply once they were put in place.
But those same models also predicted that ending the restrictions would put countries at risk of a return of the virus a few months later, forcing governments to again decide between strict restrictions or an out-of-control pandemic in the next step of a cycle that would repeat until a vaccine or therapy became available. Those countries now have a somewhat different question: are there ways of controlling the virus without resorting to a cycle of on-and-off lockdowns? For countries like the US, which implemented restrictions briefly, erratically, and half heartedly, such that peaks haven't been separated by much of a trough, the same question will become relevant if we ever get the virus under control.
A new study by a large international team uses epidemiological models to explore ways of keeping things in check while allowing most of the population to resume a semi-normal life. It finds that there are ways of handling restriction easing, but they require a combination of an effective contact tracing system, extensive testing, and a willingness of households to quarantine together.
From real world to model
The study relied on an epidemiological model—in this case, the basis was a fairly standard version that splits up the model population into pools of people who are susceptible, infected, or recovered. But the model used here was significantly more complex, thanks to the much better understanding we now have of SARS-CoV-2's behavior.
As normal, people in the susceptible pool become infected by coming into virtual contact with someone in the infected pool. But instead of going directly into the infected pool, they then experience a period of latency, in which they're not yet infectious. Some people exit latency into an asymptomatic infection, which still allows them to transmit the virus until they reach the recovered pool. Others follow a different path through a pre-symptomatic but infectious phase, through a symptomatic-and-infectious period that's modeled to have a severity that could include time spent hospitalized and/or in an intensive care unit. This allows the researchers to track the sort of strain a given level of infection would put on the health system.
To model the sort of interactions that could enable the virus to spread, the researchers took advantage of a key source of real-world data: anonymized cell phone data. In this case, they had six months of pre-pandemic cell phone location data from the Boston area, which they used in conjunction with census data. This allowed them to generate a three-layered model of interactions, tracking infection opportunities at the level of people who shared housing, those who interacted at work or socially, and those who went to school.
To provide a baseline for their model, the researchers ran it without any restrictions in place. As with other, less sophisticated models, it produced a huge peak of infections that greatly exceeded the capacity of hospitals to handle patients. At its peak, the typical infected person passed the virus on to four people in the susceptible pool. By the time things slow down, 75 percent of the population had been infected.
Restrictions, and how to end them
The researchers then switched to focusing on what happens after restrictions start being eased. They ran the model in a scenario in which an eight-week-long stay-at-home order was followed by reopening workplaces for four weeks, before most restrictions, including those on restaurants and theaters, are lifted. Schools and universities, however, remain closed. The model here successfully matched what has happened in New York City in terms of the number of contacts people typically have each day under the different restrictions.
But it also has bad news for New York City and elsewhere: a very large peak of infections happening in the wake of the full lifting of restrictions. This hasn't happened in most places, in part because many workplaces haven't reopened, and many people have adopted additional measures, such as face mask use, that limit the pandemic's spread. But it does indicate the risks of a complete reopening, especially in places where the other measures can't be guaranteed. While the surge in cases is only about half of what the model indicates we'd see if we did nothing, it's still easily enough to overwhelm healthcare systems.
But the researchers' main focus was on a way of handling reopening that they argue could greatly reduce the risk. It requires a testing capacity that's large enough that about half the symptomatic COVID-19 cases can be identified within two days of the onset of symptoms. Once identified, these people quarantine at home for two weeks. Critically, anyone who normally lives with that person also has to quarantine at home for two weeks—essentially, it treats households as single units for the purposes of quarantine. Another key to the researchers' plan is that contact tracing is efficient enough to track down a reasonable percentage of the people who have been in proximity to those who get a positive test (they try values ranging from 20 percent to 40 percent of contacts traced) and that said individuals go into quarantine.
Overall, this seems pretty reasonable. It doesn't demand that we identify asymptomatic cases or the people with symptoms with complete efficiency. It also doesn't expect high levels of successful contact tracing, which would probably require most of the population to install contact tracing applications on their smartphones. But it also needs to be acknowledged that the US' testing capabilities are nowhere near good enough to make this a reality today.
The results in this model are pretty dramatic. Even at 20-percent successRead More – Source
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