Veteran US senator John McCain has died at the age of 81, his office has said.
In a statement, a spokesperson said: "Senator John Sidney McCain III died at 4:28pm on August 25, 2018.
"With the senator when he passed were his wife Cindy and their family. At his death, he had served the United States of America faithfully for sixty years."
His death comes after his family said he had chosen to end his medical treatment for brain cancer.
The former presidential candidate, who ran against Barack Obama in 2008, revealed he had been diagnosed with an aggressive form of the disease last year.
In a statement on Friday, Mr McCain's family said he had "surpassed expectations for his survival", but the progress of the cancer and his age "render their verdict".
"With his usual strength of will, he has now chosen to discontinue medical treatment," they said.
On Saturday, Cindy McCain thanked well-wishers on Twitter, saying she was "overwhelmed by the outpouring of love and support from around the world".
Following her husband's death, she wrote: "My heart is broken. I am so lucky to have lived the adventure of loving this incredible man for 38 years.
"He passed the way he lived, on his own terms, surrounded by the people he loved, in the the place he loved best."
My heart is broken. I am so lucky to have lived the adventure of loving this incredible man for 38 years. He passed the way he lived, on his own terms, surrounded by the people he loved, in the the place he loved best.
— Cindy McCain (@cindymccain) August 26, 2018
In a statement, Mr McCain's daughter Meghan said her father was a "great fire who burned bright".
"He loved me, and I loved him. He taught me how to live," she said. "His love and his care, ever present, always unfailing, took me from a girl to a woman – and he showed me what it is to be a man."
President Donald Trump paid tribute to the Republican politician on Twitter shortly after the death was announced.
"My deepest sympathies and respect go out to the family of Senator John McCain," he wrote. "Our hearts and prayers are with you!"
My deepest sympathies and respect go out to the family of Senator John McCain. Our hearts and prayers are with you!
— Donald J. Trump (@realDonaldTrump) August 26, 2018
Secretary of Defence James Mattis said the US had "lost a man who steadfastly represented the best ideals of our country".
Mr Obama said despite their differences, they shared "a fidelity to something higher", citing "the ideals for which generations of Americans and immigrants alike have fought, marched, and sacrificed".
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He added: "We saw our political battles, even, as a privilege, something noble, an opportunity to serve as stewards of those high ideals at home, and to advance them around the world.
"We saw this country as a place where anything is possible – and citizenship as our patriotic obligation to ensure it forever remains that way."
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